Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction.
نویسندگان
چکیده
In this review we summarize recent major advances in our understanding on the molecular mechanisms, mediators, and biomarkers of acute lung injury (ALI) and alveolar-capillary barrier dysfunction, highlighting the role of immune cells, inflammatory and noninflammatory signaling events, mechanical noxae, and the affected cellular and molecular entities and functions. Furthermore, we address novel aspects of resolution and repair of ALI, as well as putative candidates for treatment of ALI, including pharmacological and cellular therapeutic means.
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ورودعنوان ژورنال:
- American journal of physiology. Lung cellular and molecular physiology
دوره 305 10 شماره
صفحات -
تاریخ انتشار 2013